Glendale, AZ (My Sportsbook) - Peyton Manning threw for 379 yards and four touchdowns to lead the Indianapolis Colts in a sound 31-10 defeat of the Arizona Cardinals in a matchup of two high-powered offenses at University of Phoenix Stadium.

Manning completed 24-of-35 passes to six different receivers, four of whom caught touchdowns. Reggie Wayne topped the list with seven grabs for 126 yards, while tight end Dallas Clark hauled in seven passes for 62 yards.

Joseph Addai rushed for 63 yards and caught a three-yard TD pass for Indianapolis (3-0), which has 12 consecutive regular-season wins -- the longest current streak in the league. The Colts offense racked up 505 total yards.

Not to be outdone, the defense was key in disrupting the flow of Kurt Warner and a dangerous Cardinals attack, intercepting Warner twice, forcing two fumbles -- one from Warner -- and producing constant pressure that led to three sacks.

Warner finished with 332 passing yards and a 10-yard touchdown to Anquan Boldin on 30-of-52 attempts. Boldin caught six balls for 83 yards and Steve Breaston posted seven receptions for 94 yards for Arizona (1-2), which bounced back from a season-opening loss to the 49ers by beating Jacksonville in Week 2.

Larry Fitzgerald checked in with 76 yards on seven grabs, while Arizona's rushing attack was nearly nonexistent with only 24 yards.