Orchard Park, NY (My Sportsbook) - Trent Edwards threw for two touchdowns and Fred Jackson gained a career-high 163 yards on 28 carries, as the Buffalo Bills defeated the Tampa Bay Buccaneers, 33-20, at Ralph Wilson Stadium.

Edwards finished with 230 yards and one interception on 21-of-31 efficiency for the Bills (1-1). Terrell Owens had 52 yards and one score on three receptions, while Derek Schouman hauled in six passes for 62 yards before being carted off in the third quarter with an apparent right knee injury.

Byron Leftwich completed 26-of-50 passes for 296 yards with three touchdowns and two interceptions for the Buccaneers (0-2), who were playing in Buffalo for the first time in team history. Kellen Winslow, Cadillac Williams and Jerramy Stevens each made a touchdown grab.

Coming off the gut-wrenching loss to New England in Week 1, in which Buffalo held an 11-point lead with three minutes remaining before Tom Brady threw a pair of touchdown passes to tight end Ben Watson, the Bills raced out to a 17- point lead against Tampa Bay in the first quarter.