Flushing Meadows, NY (My Sportsbook) - Reigning five-time champion Roger Federer was an easy fourth-round winner Monday at the U.S. Open, but the magical run for American John Isner came to an end.

The world No. 1 Federer handled 14th-seeded Spaniard Tommy Robredo 7-5, 6-2, 6-2 on Labor Day at the Billie Jean King USTA National Tennis Center. The amazing Federer has won his last 38 matches in New York and hasn't lost here since 2003.

The 6-foot-9 Isner, who upset fellow countryman and fifth seed Andy Roddick on Saturday, lost to 10th-seeded Fernando Verdasco as the Spaniard scored a 4-6, 6-4, 6-4, 6-4 victory. That means there will not be an American man in the quarterfinals for the first time in the tournament's history.

"I knew that. I didn't really care. I wanted to keep it going," said Isner. "If you would have told me I'd be the last American, only one American to make the final 16, I probably would have thought maybe one or two more would have."

Federer recorded the first break of the match against Robredo to grab a 6-5 edge in the opening set, the held his serve to close out the stanza.

The 28-year-old then broke Robredo for a 2-1 lead in the second set and cruised the rest of the way on Day 8 of the fortnight. The Swiss broke the Spaniard to open the third set and barely broke a sweat at Ashe Stadium, as he capped his day with a match-ending ace against the helpless Robredo.

"It was a key to get the break and not having to maybe go through the tiebreak," said Federer. "I was even down break points, so it was kind of tough. Once I got the lead, I could also hit a bit more freely. That didn't allow him to play his game anymore. I got on top of him and played good tennis."

Federer moved on in 1 hour, 48 minutes with the help of nine aces and five breaks. The super Swiss held his serve throughout the predictable bout and is now 9-0 lifetime against Robredo.

The 15-time major champion Federer, who currently holds three of the four major titles, beat Andy Murray in last year's finale here in Flushing. The super Swiss became the men's all-time Grand Slam king when he titled at Wimbledon in July.

Federer's quarterfinal opponent will be 12th-seeded Robin Soderling, who was defeated by the Basel native in straight sets in June's French Open final. Federer also beat Soderling in the fourth round at Wimbledon this summer.

The Swedish Soderling reached his first-ever U.S. Open quarterfinal by getting past eighth-seeded Russian Nikolay Davydenko 7-5, 3-6, 6-2, as the Russian veteran retired after the third set, citing a leg injury on Monday.

The 25-year-old Soderling is now 13-2 over his last three Grand Slam events.

Isner had 13 aces on Monday. That was 25 less than he fired on Saturday in the marathon five-setter against Roddick. This was still the best Grand Slam result of Isner's career, while Verdasco is into the quarterfinals for a second time in a major tournament in 2009. He reached the semifinals at the Australian Open before losing in five sets to eventual champion Rafael Nadal.

Verdasco's next opponent will be fourth-seeded Serbian Novak Djokovic, who eased past 15th seed Radek Stepanek of the Czech Republic, 6-1, 6-3, 6-3. Djokovic was the 2007 U.S. Open runner-up to Federer.

After the match, Djokovic continued to woo the fans by impersonating John McEnroe, throwing down his racket, demanding the ball and mock-arguing an umpire's call.

To the delight of the crowd, McEnroe raced down from his spot in the television booth and then played a few points against Djokovic. before the two shook hands at center court.

The men's fourth round will conclude here on Tuesday, including matches for last year's U.S. Open runner-up Murray and third-seeded former world No. 1 Nadal. The second-seeded Murray will take on 16th-seeded Croat Marin Cilic, while the Aussie Open champion Nadal will face 13th-seeded Frenchman Gael Monfils.

Two other Day-9 fourth-rounders will pit sixth-seeded Argentine Juan Martin del Potro against 24th-seeded Spaniard Juan Carlos Ferrero and seventh-seeded Frenchman Jo-Wilfried Tsonga versus 11th-seeded Chilean Fernando Gonzalez. The former world No. 1 Ferrero was a U.S. Open runner-up back in 2003.