Cincinnati, OH (My Sportsbook) - Less than two days after finally signing his rookie contract with the Bengals, offensive lineman Andre Smith fractured his foot in Tuesday's practice and will be out indefinitely.

"Andre suffered a small fracture in his left foot during a non-contact drill," said Cincinnati head coach Marvin Lewis in a statement. "Our medical staff tells me the injury will not require surgery. It's too soon to closely predict how long it will be before he can return to practice. But it looks like he's going to miss a few weeks."

The sixth overall pick in this season's draft out of Alabama, Smith had just signed a deal that was reportedly worth up to $42 million after a 30-day holdout. He was the second to last first-round pick to agree to terms, with San Francisco's Michael Crabtree the lone holdout remaining.

The Bengals have had terrible luck when it comes to their top draft picks and injuries, as Smith becomes the fifth top pick in six years to suffer a major injury in his rookie season.

In 2004, Chris Perry played in just two games because of a sports hernia; David Pollack suffered a knee sprain in 2005 and broke his neck in 2006, ending his career; Kenny Irons tore his ACL in a preseason game in 2007, also ending his career; last year's pick, Keith Rivers, missed nine games because of a broken jaw.

Because the 6-foot-4, 340-pound Smith has missed a significant amount of time, including the Bengals' first three preseason games, the team may have to use a two-week roster exemption -- meaning he can practice but not play in a game.

Cincinnati plays its final preseason game September 3 against Indianapolis, then opens the season September 13 against Denver.