(My Sportsbook) - Carlos Zambrano returns to Miller Park for the first time since tossing a no-hitter there, as the Chicago Cubs play the middle test of their three-game set with the Milwaukee Brewers.

Zambrano, though, did not toss the no-no against the Brewers, he did so against the Houston Astros, who were playing in Milwaukee after being displaced by Hurricane Ike.

The 27-year-old right-hander got his 2009 campaign off on the right foot on Monday in Houston, as he held the Astros to just a run and five hits in six innings to earn his first Opening Day win in five chances. He also walked three batters and struck out six.

Zambrano was masterful in three starts against the Brewers last season, going 1-0 with a 0.43 ERA. He is 10-8 lifetime against them with a 3.65 ERA in 23 games, 22 of which have been starts.

Milwaukee, meanwhile, will hand the ball to righty Dave Bush, who opens the year as the Brewers' fifth starter. Bush pitched an inning in relief in his team's Opening Day loss against the San Francisco Giants on Tuesday, surrendering two runs and three hits in the 10-6 setback.

Bush, who was 9-10 last season with a 4.18 ERA, is just 1-7 in his career against the Cubs with a 4.84 ERA in 12 games, 11 starts.

Milwaukee won the opener of this series in dramatic fashion on Friday, as Rickie Weeks doubled home the tying run in the ninth, took third on a ball in the dirt and scored the winning run on an infield hit with a head-first slide just ahead of the tag to give the Brewers a thrilling 4-3 victory.

Carlos Villanueva (1-0) set down Chicago in order in the ninth and Kevin Gregg (0-1) returned to pitch the bottom half after being called upon to close out the eighth. Jason Kendall was retired on a ground out but Chris Duffy, who was part of a double switch in the top part of the inning, drew a walk. Weeks turned on a low, 2-1 fastball for a double that sailed over the head of Alfonso Soriano in left and one-hopped against the wall.

Duffy scored to tie the game and the heads-up Weeks took third when Gregg bounced a ball in the dirt to Corey Hart, who went on to walk. Ryan Braun sent a dribbler to short and Weeks broke for home. Ryan Theriot rushed the throw, bounced it just in front of Koyie Hill and Weeks beat the tag to send the 45,455 fans - the second-largest crowd in Miller Park history - into a frenzy.

Braun knocked in two of Milwaukee's four runs while Hart homered and walked twice. Weeks scored twice and also robbed Aramis Ramirez of a base-hit with two men on in the seventh while down a run.

Hill, starting behind the plate for 2008 NL Rookie of the Year Geovany Soto, hit a two-run homer and Milton Bradley added a solo shot for Chicago, which entered this series on the heels of taking two of three games from the Houston Astros.

Chicago won nine of its 16 meetings with the Brewers last season, including five of the seven matchups held in Milwaukee.