(My Sportsbook) - Carlos Silva hopes for a fresh start as he begins his second season with the Seattle Mariners, who continue their season-opening four-game series with the Minnesota Twins at the Metrodome tonight.

Silva, who is in the second year of a four-year, $48 million deal, had a forgettable first season with the Mariners, going a putrid 4-15 while pitching to a 6.46 earned run average. He was even worse as the season went on, going just 1-15 over his final 23 starts.

The 29-year-old right-hander, though, lost 35 pounds this offseason.

Silva won 49 games with the Twins from 2004-07. However, he is 0-1 lifetime against his former team while surrendering 12 runs and 11 hits in two games (1 start). Silva lasted just 3 1/3 frames against Minnesota in a 9-3 setback on August 15, allowing nine runs and nine hits.

Minnesota, meanwhile, will give the ball to righty Kevin Slowey, who has never faced the Mariners. Slowey was tied for the team lead in wins last season, posting a 12-11 record to go along with a 3.99 ERA.

One of Seattle's biggest question marks entering the year reared its ugly head on Tuesday, as the Twins' Alexi Casilla's two-run, two-out single in the bottom of the ninth capped a three-run rally in Minnesota's 6-5 victory.

The Mariners seemed poised to hand Erik Bedard a victory, carrying a 5-3 edge into the ninth, but newly-appointed closer Brandon Morrow (0-1) walked the bases loaded with two outs before being replaced by Miguel Batista.

After Denard Span singled home a run to pull the Twins within one, Casilla wasted no time with a base hit to center on a first-pitch fastball, scoring pinch-runner Brendan Harris and Brian Buscher with the tying and winning runs.

Twins reliever Luis Ayala (1-0) was the beneficiary of the ninth-inning rally after giving up one run on two hits in one frame. Michael Cuddyer finished 2- for-4 with two runs batted in for the Twins, who got just five frames from starting hurler Nick Blackburn.

Blackburn gave up four runs on eight hits with three walks, while his counterpart Bedard surrendered three runs on six hits with eight strikeouts over five frames.

Endy Chavez finished 3-for-5 with two runs scored and two RBI for Seattle, while Adrian Beltre knocked home a pair in defeat.

Ken Griffey Jr. finished 0-for-3 one night after belting the 612th home run of his career. Griffey's next homer will give him 400 in a Mariners uniform and will make him the first major leaguer to hit 400 with one club and 200 with another.

Griffey, who totaled 210 homers with Cincinnati from 2000-08, has hit 25 homers in the Metrodome - the most he's had in any opposing ballpark.

The Twins went 5-4 against Seattle last season.