Manchester, England (My Sportsbook) - The Manchester United powerhouse trio of Ryan Giggs, Louis Saha and captain Gary Neville will all be out of uniform for the England club's Champions League match against Copenhagen on Wednesday, due to injuries.

This game could possibly be one of a couple that Giggs and Neville will miss, as the skipper will also sit for the squad's Premiership contest this weekend against Portsmouth, due to a nagging calf issue. Giggs might or might not be sidelined for Saturday's Old Trafford matchup, as a result of a hamstring problem.

Saha could be probable for Saturday as well, since the three-goal tallying striker suffered a knee injury during the season.

"It's a blow not to have such experienced players," Manager Sir Alex Ferguson told the club's website. "But we've got a big squad."

The news isn't all downhill for the Reds, as defender Patrice Evra reported fit to play, despite a limping exit after suffering an ankle injury during last weekend's fixture. Man U. will also bring up teenage full-back Kieran Lee for his first European trip.

Other changes will be made in addition to fill the holes the three stars void. Cristiano Ronaldo will shift to the left flank for Giggs and Darren Fletcher will stay on the right, while Saha's offensive power will be covered by Ole Gunnar Solskjaer and Alan Smith.

Fellow striker Wayne Rooney's best outing of the year couldn't have come at a better time, as the Red's goal-leader with five, recorded a hat-trick performance in Saturday's 4-0 shutout of Bolton. Manchester only hopes that the momentum carries into mid-week.

United only needs a point in Champions play to guarantee a Group F advancement into the knockout stage.